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Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia

Exchange transfusion of large volumes of hemoglobin (Hb)-based oxygen carriers can protect the brain from middle cerebral artery occlusion (MCAO). Hb in the carboxy state (COHb) may provide protection at relatively low volumes by enhancing vasodilation. We determined whether transfusion of rats with...

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Detalhes bibliográficos
Main Authors: Zhang, Jian, Cao, Suyi, Kwansa, Herman, Crafa, Daina, Kibler, Kathleen K., Koehler, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544507/
https://ncbi.nlm.nih.gov/pubmed/23042910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01079.2012
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