Transglutaminase inhibitors attenuate vascular calcification in a preclinical model

OBJECTIVE: In vitro, transglutaminase 2 (TG2)-mediated activation of the β-catenin signaling pathway is central in warfarin-induced calcification, warranting inquiry into the importance of this signaling axis as a target for preventive therapy of vascular calcification in vivo. METHODS AND RESULTS:...

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Main Authors: Beazley, Kelly E., Banyard, Derek, Lima, Florence, Deasey, Stephanie C., Nurminsky, Dmitry I., Konoplyannikov, Mikhail, Nurminskaya, Maria V.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544469/
https://ncbi.nlm.nih.gov/pubmed/23117658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300260
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