Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions

Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease characterized by degeneration of motor neurons, resulting in paralysis and death. A pathological hallmark of the degenerating motor neurons in most ALS patients is the presence of cytoplasmic inclusions conta...

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Bibliographic Details
Main Authors: Hart, Michael P., Brettschneider, Johannes, Lee, Virginia M.Y., Trojanowski, John Q., Gitler, Aaron D.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543833/
https://ncbi.nlm.nih.gov/pubmed/22526021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-0985-5
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