Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1

Colonic chloride secretion is regulated via the neurohormonal and immune systems. Exogenous chemicals (e.g., butyrate, propionate) can affect chloride secretion. Capsaicin, the pungent ingredient of the chili peppers, exerts various effects on gastrointestinal function. Capsaicin is known to activat...

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Главные авторы: Bouyer, Patrice G., Tang, Xu, Weber, Christopher R., Shen, Le, Turner, Jerrold R., Matthews, Jeffrey B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2013
Предметы:
Mucosal Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543646/
https://ncbi.nlm.nih.gov/pubmed/23139219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00483.2011
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