Activated PKCδ and PKCϵ Inhibit Epithelial Chloride Secretion Response to cAMP via Inducing Internalization of the Na(+)-K(+)-2Cl(−) Cotransporter NKCC1

The basolateral Na(+)-K(+)-2Cl(−) cotransporter (NKCC1) is a key determinant of transepithelial chloride secretion and dysregulation of chloride secretion is a common feature of many diseases including secretory diarrhea. We have previously shown that activation of protein kinase C (PKC) markedly re...

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Autores principales: Tang, Jun, Bouyer, Patrice, Mykoniatis, Andreas, Buschmann, Mary, Matlin, Karl S., Matthews, Jeffrey B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962506/
https://ncbi.nlm.nih.gov/pubmed/20732874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.137380
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