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Activated PKCδ and PKCϵ Inhibit Epithelial Chloride Secretion Response to cAMP via Inducing Internalization of the Na(+)-K(+)-2Cl(−) Cotransporter NKCC1
The basolateral Na(+)-K(+)-2Cl(−) cotransporter (NKCC1) is a key determinant of transepithelial chloride secretion and dysregulation of chloride secretion is a common feature of many diseases including secretory diarrhea. We have previously shown that activation of protein kinase C (PKC) markedly re...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2962506/ https://ncbi.nlm.nih.gov/pubmed/20732874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.137380 |
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