Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

BACKGROUND: Mutations in either Aβ Precursor protein (APP) or genes that regulate APP processing, such as BRI2/ITM2B and PSEN1/PSEN2, cause familial dementias. Although dementias due to APP/PSEN1/PSEN2 mutations are classified as familial Alzheimer disease (FAD) and those due to mutations in BRI2/IT...

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Detalhes bibliográficos
Main Authors: Tamayev, Robert, Akpan, Nsikan, Arancio, Ottavio, Troy, Carol M, D’Adamio, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543220/
https://ncbi.nlm.nih.gov/pubmed/23217200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-60
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