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Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation

In the absence of elongation factor EF-G, ribosomes undergo spontaneous, thermally driven fluctuation between the pre-translocation (classical) and intermediate (hybrid) states of translocation. These fluctuations do not result in productive mRNA translocation. Extending previous findings that the a...

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Hlavní autoři: Ermolenko, Dmitri N., Cornish, Peter V., Ha, Taekjip, Noller, Harry F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543091/
https://ncbi.nlm.nih.gov/pubmed/23249745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035964.112
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