Cysteine Scanning Mutagenesis of Transmembrane Helix 3 of a Brain Glutamate Transporter Reveals Two Conformationally Sensitive Positions

Glutamate transporters in the brain remove the neurotransmitter from the synapse by cotransport with three sodium ions into the surrounding cells. Recent structural work on an archaeal homolog suggests that, during substrate translocation, the transport domain, including the peripheral transmembrane...

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Detalhes bibliográficos
Main Authors: Silverstein, Nechama, Crisman, Thomas J., Forrest, Lucy R., Kanner, Baruch I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543046/
https://ncbi.nlm.nih.gov/pubmed/23188832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403576
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