Cysteine Scanning Mutagenesis of Transmembrane Helix 3 of a Brain Glutamate Transporter Reveals Two Conformationally Sensitive Positions

Glutamate transporters in the brain remove the neurotransmitter from the synapse by cotransport with three sodium ions into the surrounding cells. Recent structural work on an archaeal homolog suggests that, during substrate translocation, the transport domain, including the peripheral transmembrane...

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Hlavní autoři: Silverstein, Nechama, Crisman, Thomas J., Forrest, Lucy R., Kanner, Baruch I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543046/
https://ncbi.nlm.nih.gov/pubmed/23188832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403576
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