Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons

Hydroxylated analogues of the anticancer topoisomerase I (Top1) inhibitors indotecan (LMP400) and indimitecan (LMP76) have been prepared because: 1) a variety of potent Top1 poisons are known that contain strategically placed hydroxyl groups, which provides a clear rationale for incorporating them i...

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Main Authors: Cinelli, Maris A., Reddy, P.V. Narasimha, Lv, Peng-Cheng, Liang, Jian-Hua, Chen, Lian, Agama, Keli, Pommier, Yves, van Breemen, Richard B., Cushman, Mark
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542640/
https://ncbi.nlm.nih.gov/pubmed/23215354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300519w
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