Gain-of-Function Lipoprotein Lipase Variant rs13702 Modulates Lipid Traits through Disruption of a MicroRNA-410 Seed Site

Genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with lipid phenotypes. However, data supporting a functional role for these variants in the context of lipid metabolism are scarce. We investigated the association of the lipoprotein lipase (LPL)...

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Main Authors: Richardson, Kris, Nettleton, Jennifer A., Rotllan, Noemi, Tanaka, Toshiko, Smith, Caren E., Lai, Chao-Qiang, Parnell, Laurence D., Lee, Yu-Chi, Lahti, Jari, Lemaitre, Rozenn N., Manichaikul, Ani, Keller, Margaux, Mikkilä, Vera, Ngwa, Julius, van Rooij, Frank J.A., Ballentyne, Christie M., Borecki, Ingrid B., Cupples, L. Adrienne, Garcia, Melissa, Hofman, Albert, Ferrucci, Luigi, Mozaffarian, Dariush, Perälä, Mia-Maria, Raitakari, Olli, Tracy, Russell P., Arnett, Donna K., Bandinelli, Stefania, Boerwinkle, Eric, Eriksson, Johan G., Franco, Oscar H., Kähönen, Mika, Nalls, Michael, Siscovick, David S., Houston, Denise K., Psaty, Bruce M., Viikari, Jorma, Witteman, Jacqueline C.M., Goodarzi, Mark O., Lehtimäki, Terho, Liu, Yongmei, Zillikens, M. Carola, Chen, Yii-Der I., Uitterlinden, André G., Rotter, Jerome I., Fernandez-Hernando, Carlos, Ordovas, Jose M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542456/
https://ncbi.nlm.nih.gov/pubmed/23246289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.10.020
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