Gain-of-Function Lipoprotein Lipase Variant rs13702 Modulates Lipid Traits through Disruption of a MicroRNA-410 Seed Site

Genome-wide association studies (GWAS) have identified hundreds of genetic variants that are associated with lipid phenotypes. However, data supporting a functional role for these variants in the context of lipid metabolism are scarce. We investigated the association of the lipoprotein lipase (LPL)...

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Κύριοι συγγραφείς: Richardson, Kris, Nettleton, Jennifer A., Rotllan, Noemi, Tanaka, Toshiko, Smith, Caren E., Lai, Chao-Qiang, Parnell, Laurence D., Lee, Yu-Chi, Lahti, Jari, Lemaitre, Rozenn N., Manichaikul, Ani, Keller, Margaux, Mikkilä, Vera, Ngwa, Julius, van Rooij, Frank J.A., Ballentyne, Christie M., Borecki, Ingrid B., Cupples, L. Adrienne, Garcia, Melissa, Hofman, Albert, Ferrucci, Luigi, Mozaffarian, Dariush, Perälä, Mia-Maria, Raitakari, Olli, Tracy, Russell P., Arnett, Donna K., Bandinelli, Stefania, Boerwinkle, Eric, Eriksson, Johan G., Franco, Oscar H., Kähönen, Mika, Nalls, Michael, Siscovick, David S., Houston, Denise K., Psaty, Bruce M., Viikari, Jorma, Witteman, Jacqueline C.M., Goodarzi, Mark O., Lehtimäki, Terho, Liu, Yongmei, Zillikens, M. Carola, Chen, Yii-Der I., Uitterlinden, André G., Rotter, Jerome I., Fernandez-Hernando, Carlos, Ordovas, Jose M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2013
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Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542456/
https://ncbi.nlm.nih.gov/pubmed/23246289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.10.020
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