Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time

The molecular reaction mechanism of the GTPase-activating protein (GAP)-catalyzed GTP hydrolysis by Ras was investigated by time resolved Fourier transform infrared (FTIR) difference spectroscopy using caged GTP (P(3)-1-(2-nitro)phenylethyl guanosine 5′-O-triphosphate) as photolabile trigger. This a...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Allin, Christoph, Ahmadian, Mohammad Reza, Wittinghofer, Alfred, Gerwert, Klaus
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35414/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11438727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131549798
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