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Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA
MxA is an interferon-induced dynamin-like GTPase with wide-ranging antiviral activity, which hinges upon detection of unique viral structures that differ across virus families. Despite elucidation of its structure, the basis of MxA antiviral specificity remains enigmatic. We used an evolution-guided...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540999/ https://ncbi.nlm.nih.gov/pubmed/23084925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.09.005 |
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