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Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA

MxA is an interferon-induced dynamin-like GTPase with wide-ranging antiviral activity, which hinges upon detection of unique viral structures that differ across virus families. Despite elucidation of its structure, the basis of MxA antiviral specificity remains enigmatic. We used an evolution-guided...

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Bibliografski detalji
Glavni autori: Mitchell, Patrick S., Patzina, Corinna, Emerman, Michael, Haller, Otto, Malik, Harmit S., Kochs, Georg
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540999/
https://ncbi.nlm.nih.gov/pubmed/23084925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.09.005
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