p53-Independent Roles of MDM2 in NF-κB Signaling: Implications for Cancer Therapy, Wound Healing, and Autoimmune Diseases

Murine double minute-2 (MDM2) is an intracellular molecule with multiple biologic functions. It serves as a negative regulator of p53 and thereby limits cell cycle arrest and apoptosis. Because MDM2 blockade suppresses tumor cell growth in vitro and in vivo, respective MDM2 inhibition is currently e...

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Main Authors: Thomasova, Dana, Mulay, Shrikant R, Bruns, Hauke, Anders, Hans-Joachim
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540936/
https://ncbi.nlm.nih.gov/pubmed/23308042
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