Imaging Epigenetic Regulation by Histone Deacetylases in the Brain using PET/MRI with (18)F-FAHA

Epigenetic modifications mediated by histone deacetylases (HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors (HDACIs) have shown promise in therapy. However, pharmacodynamic profiles of many HDACIs in the brain remain largely unknown due to the lack o...

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Main Authors: Yeh, Hsien-Hsien, Tian, Mei, Hinz, Rainer, Young, Daniel, Shavrin, Alexander, Mukhapadhyay, Uday, Flores, Leo G., Balatoni, Julius, Soghomonyan, Suren, Jeong, Hwan J., Pal, Ashutosh, Uthamanthil, Rajesh, Jackson, James N., Nishii, Ryuichi, Mizuma, Hiroshi, Onoe, Hirotaka, Kagawa, Shinya, Higashi, Tatsuya, Fukumitsu, Nobuyoshi, Alauddin, Mian, Tong, William, Herholz, Karl, Gelovani, Juri G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540799/
https://ncbi.nlm.nih.gov/pubmed/22995777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2012.09.019
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