The PI3K Isoforms p110α and p110δ are Essential for Pre-B Cell Receptor Signaling and B Cell Development

B cell development is controlled by a series of checkpoints that ensure that the immunoglobulin (Ig)-encoding genes are assembled in frame to produce a functional B cell receptor (BCR) and antibodies. The BCR consists of Ig proteins in complex with the immunoreceptor tyrosine-based activation motif...

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Autores principales: Ramadani, Faruk, Bolland, Daniel J., Garcon, Fabien, Emery, Juliet L., Vanhaesebroeck, Bart, Corcoran, Anne E., Okkenhaug, Klaus
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540743/
https://ncbi.nlm.nih.gov/pubmed/20699475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001104
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