In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites

Microcin B17 (MccB17) is a 3.1-kDa Escherichia coli antibiotic that contains thiazole and oxazole heterocycles in a peptide backbone. MccB17 inhibits its cellular target, DNA gyrase, by trapping the enzyme in a complex that is covalently bound to double-strand cleaved DNA, in a manner similar to the...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Zamble, Deborah B., Miller, Deborah A., Heddle, Jonathan G., Maxwell, Anthony, Walsh, Christopher T., Hollfelder, Florian
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2001
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35407/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11427730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141225698
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