Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor.

Drugs that inhibit the activity of DNA gyrase fall almost exclusively into two structural classes, the quinolones and the coumarins. A third class of DNA gyrase inhibitor is defined by the ribosomally synthesized peptide antibiotic microcin B17 (MccB17). MccB17 contains 43 amino acid residues, but 1...

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Bibliographic Details
Main Authors: Yorgey, P, Lee, J, Kördel, J, Vivas, E, Warner, P, Jebaratnam, D, Kolter, R
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC43817/
https://ncbi.nlm.nih.gov/pubmed/8183941
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