In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites

Microcin B17 (MccB17) is a 3.1-kDa Escherichia coli antibiotic that contains thiazole and oxazole heterocycles in a peptide backbone. MccB17 inhibits its cellular target, DNA gyrase, by trapping the enzyme in a complex that is covalently bound to double-strand cleaved DNA, in a manner similar to the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zamble, Deborah B., Miller, Deborah A., Heddle, Jonathan G., Maxwell, Anthony, Walsh, Christopher T., Hollfelder, Florian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35407/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11427730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141225698
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