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Methylation and Immunoexpression of p16(INK4a) Tumor Suppressor Gene in Primary Breast Cancer Tissue and Their Quantitative p16(INK4a) Hypermethylation in Plasma by Real-Time PCR
BACKGROUND: The p16(INK4a) gene methylation has been reported to be a major tumorigenic mechanism. METHODS: We evaluated the methylation status of the p16(INK4a) genes in 231 invasive breast cancer and 90 intraductal carcinoma specimens using a methylation-specific polymerase chain reaction and p16...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Korean Society of Pathologists and The Korean Society for Cytopathology
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540333/ https://ncbi.nlm.nih.gov/pubmed/23323106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4132/KoreanJPathol.2012.46.6.554 |
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