p16(INK4a )hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma

BACKGROUND: Tumor suppressor genes p53 and p16(INK4a )and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the aberrant methylation of the p16 gene and its impact on p16(INK4a )protein exp...

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Hauptverfasser: Taghavi, Noushin, Biramijamal, Firouzeh, Sotoudeh, Masoud, Khademi, Hooman, Malekzadeh, Reza, Moaven, Omeed, Memar, Bahram, A'rabi, Azadeh, Abbaszadegan, Mohammad Reza
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868052/
https://ncbi.nlm.nih.gov/pubmed/20388212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-138
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