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p16(INK4a )hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma
BACKGROUND: Tumor suppressor genes p53 and p16(INK4a )and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the aberrant methylation of the p16 gene and its impact on p16(INK4a )protein exp...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2868052/ https://ncbi.nlm.nih.gov/pubmed/20388212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-138 |
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