Methylation and Immunoexpression of p16(INK4a) Tumor Suppressor Gene in Primary Breast Cancer Tissue and Their Quantitative p16(INK4a) Hypermethylation in Plasma by Real-Time PCR

BACKGROUND: The p16(INK4a) gene methylation has been reported to be a major tumorigenic mechanism. METHODS: We evaluated the methylation status of the p16(INK4a) genes in 231 invasive breast cancer and 90 intraductal carcinoma specimens using a methylation-specific polymerase chain reaction and p16...

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Main Authors: Lee, Jae Jun, Ko, Eunkyung, Cho, Junhun, Park, Ha Young, Lee, Jeong Eon, Nam, Seok Jin, Kim, Duk-Hwan, Cho, Eun Yoon
Formato: Artigo
Idioma:Inglês
Publicado: The Korean Society of Pathologists and The Korean Society for Cytopathology 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540333/
https://ncbi.nlm.nih.gov/pubmed/23323106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4132/KoreanJPathol.2012.46.6.554
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