The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor(+) Innate Lymphoid Cells

Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα(+) innate lymphoid cells (ILCs) were potent promoters of disease in Tbx21(−/−)Rag2(−/−) ulcerative colitis (TRUC) mice. TNF-α pro...

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Detalhes bibliográficos
Main Authors: Powell, Nick, Walker, Alan W., Stolarczyk, Emilie, Canavan, James B., Gökmen, M. Refik, Marks, Ellen, Jackson, Ian, Hashim, Ahmed, Curtis, Michael A., Jenner, Richard G., Howard, Jane K., Parkhill, Julian, MacDonald, Thomas T., Lord, Graham M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540260/
https://ncbi.nlm.nih.gov/pubmed/23063332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.09.008
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