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The Conserved Phenylalanine in the K(+) Channel Voltage-Sensor Domain Creates a Barrier with Unidirectional Effects
Voltage-gated ion channels are crucial for regulation of electric activity of excitable tissues such as nerve cells, and play important roles in many diseases. During activation, the charged S4 segment in the voltage sensor domain translates across a hydrophobic core forming a barrier for the gating...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540256/ https://ncbi.nlm.nih.gov/pubmed/23332060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.3827 |
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