C-terminal turn stability determines assembly: differences between Aβ40 and Aβ42

Oligomerization of the amyloid β-protein (Aβ) is a seminal event in Alzheimer’s disease (AD). Aβ42, which is only two amino acids longer than Aβ40, is particularly pathogenic. Why this is so has not been elucidated fully. We report here results of computational and experimental studies revealing a C...

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Main Authors: Roychaudhuri, Robin, Yang, Mingfeng, Deshpande, Atul, Cole, Gregory M., Frautschy, Sally, Lomakin, Aleksey, Benedek, George B., Teplow, David B.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540122/
https://ncbi.nlm.nih.gov/pubmed/23154165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.11.006
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