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C-terminal turn stability determines assembly: differences between Aβ40 and Aβ42
Oligomerization of the amyloid β-protein (Aβ) is a seminal event in Alzheimer’s disease (AD). Aβ42, which is only two amino acids longer than Aβ40, is particularly pathogenic. Why this is so has not been elucidated fully. We report here results of computational and experimental studies revealing a C...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540122/ https://ncbi.nlm.nih.gov/pubmed/23154165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.11.006 |
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