Mechanistic Investigation of the Inhibition of Aβ42 Assembly and Neurotoxicity by Aβ42 C-terminal Fragments

Oligomeric forms of amyloid β-protein (Aβ) are key neurotoxins in Alzheimer's disease (AD). Previously, we found that C-terminal fragments (CTFs) of Aβ42 interfered with assembly of full-length Aβ42 and inhibited Aβ42-induced toxicity. To decipher the mechanism(s) by which CTFs affect Aβ42 asse...

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Detalhes bibliográficos
Main Authors: Li, Huiyuan, Monien, Bernhard H., Lomakin, Aleksey, Zemel, Reeve, Fradinger, Erica A., Tan, Miao, Spring, Sean M., Urbanc, Brigita, Xie, Cui-Wei, Benedek, George B., Bitan, Gal
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912417/
https://ncbi.nlm.nih.gov/pubmed/20568734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100773g
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