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Biophysical Characterization of Aβ42 C-terminal Fragments—Inhibitors of Aβ42 Neurotoxicity

A key event in Alzheimer’s disease (AD) is age-dependent, brain accumulation of amyloid β-protein (Aβ) leading to Aβ self-association into neurotoxic oligomers. Previously, we showed that Aβ oligomerization and neurotoxicity could be inhibited by C-terminal fragments (CTFs) of Aβ42. Because these CT...

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書誌詳細
主要な著者: Li, Huiyuan, Monien, Bernhard H., Fradinger, Erica A., Urbanc, Brigita, Bitan, Gal
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831638/
https://ncbi.nlm.nih.gov/pubmed/20050679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902075h
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