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Biophysical Characterization of Aβ42 C-terminal Fragments—Inhibitors of Aβ42 Neurotoxicity
A key event in Alzheimer’s disease (AD) is age-dependent, brain accumulation of amyloid β-protein (Aβ) leading to Aβ self-association into neurotoxic oligomers. Previously, we showed that Aβ oligomerization and neurotoxicity could be inhibited by C-terminal fragments (CTFs) of Aβ42. Because these CT...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831638/ https://ncbi.nlm.nih.gov/pubmed/20050679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902075h |
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