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A two-step strategy for SAR studies of N- methylated Aβ42 C-terminal fragments as Aβ42 toxicity inhibitors
Neurotoxic Aβ42 oligomers are believed to be the main cause of Alzheimer’s disease. Previously, we found that the C-terminal fragments (CTFs), Aβ(30–42) and Aβ(31–42) were the most potent inhibitors of Aβ42 oligomerization and toxicity in a series of Aβ(x–42) peptides, (x=28–39). Therefore, we chose...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517043/ https://ncbi.nlm.nih.gov/pubmed/22307963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100584 |
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