C-terminal turn stability determines assembly: differences between Aβ40 and Aβ42

Oligomerization of the amyloid β-protein (Aβ) is a seminal event in Alzheimer’s disease (AD). Aβ42, which is only two amino acids longer than Aβ40, is particularly pathogenic. Why this is so has not been elucidated fully. We report here results of computational and experimental studies revealing a C...

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Bibliographic Details
Main Authors: Roychaudhuri, Robin, Yang, Mingfeng, Deshpande, Atul, Cole, Gregory M., Frautschy, Sally, Lomakin, Aleksey, Benedek, George B., Teplow, David B.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540122/
https://ncbi.nlm.nih.gov/pubmed/23154165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.11.006
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