Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) analogs as glutaminase inhibitors

Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) that has served as a molecular probe to determine the therapeutic potential of GLS inhibition. In an attempt to identify more potent GLS inhibitors wit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shukla, Krupa, Ferraris, Dana V., Thomas, Ajit G., Stathis, Marigo, Duvall, Bridget, Delahanty, Greg, Alt, Jesse, Rais, Rana, Rojas, Camilo, Gao, Ping, Xiang, Yan, Dang, Chi V., Slusher, Barbara S., Tsukamoto, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539823/
https://ncbi.nlm.nih.gov/pubmed/23151085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301191p
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados