Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

The release of GA (mitochondrial glutaminase) from neurons following acute ischaemia or during chronic neurodegenerative diseases may contribute to the propagation of glutamate excitotoxicity. Thus an inhibitor that selectively inactivates the released GA may limit the accumulation of excess glutama...

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Bibliografiska uppgifter
Huvudupphovsmän: Robinson, Mary M., Mcbryant, Steven J., Tsukamoto, Takashi, Rojas, Camilo, Ferraris, Dana V., Hamilton, Sean K., Hansen, Jeffrey C., Curthoys, Norman P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2007
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049044/
https://ncbi.nlm.nih.gov/pubmed/17581113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070039
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