Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

The release of GA (mitochondrial glutaminase) from neurons following acute ischaemia or during chronic neurodegenerative diseases may contribute to the propagation of glutamate excitotoxicity. Thus an inhibitor that selectively inactivates the released GA may limit the accumulation of excess glutama...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Robinson, Mary M., Mcbryant, Steven J., Tsukamoto, Takashi, Rojas, Camilo, Ferraris, Dana V., Hamilton, Sean K., Hansen, Jeffrey C., Curthoys, Norman P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Portland Press Ltd. 2007
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049044/
https://ncbi.nlm.nih.gov/pubmed/17581113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070039
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