Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

The release of GA (mitochondrial glutaminase) from neurons following acute ischaemia or during chronic neurodegenerative diseases may contribute to the propagation of glutamate excitotoxicity. Thus an inhibitor that selectively inactivates the released GA may limit the accumulation of excess glutama...

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Detalhes bibliográficos
Main Authors: Robinson, Mary M., Mcbryant, Steven J., Tsukamoto, Takashi, Rojas, Camilo, Ferraris, Dana V., Hamilton, Sean K., Hansen, Jeffrey C., Curthoys, Norman P.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049044/
https://ncbi.nlm.nih.gov/pubmed/17581113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070039
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