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3-Arylcoumarin Derivatives Manifest Anti-proliferative Activity through Hsp90 Inhibition

[Image: see text] The potential therapeutic benefits associated with Hsp90 modulation for the treatment of cancer and neurodegenerative diseases highlight the importance of identifying novel Hsp90 scaffolds. KU-398, a novobiocin analogue, and silybin were recently identified as new Hsp90 inhibitors....

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Main Authors: Zhao, Huiping, Yan, Bin, Peterson, Laura B., Blagg, Brian S. J.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2012
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539803/
https://ncbi.nlm.nih.gov/pubmed/23316269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300018e
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