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Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

Alpha synuclein (SYN) is a central player in the pathogenesis of sporadic and familial Parkinson's disease (PD). SYN aggregation and oxidative stress are associated and enhance each other's toxicity. It is unknown whether the redox-sensitive transcription factor nuclear factor erythroid 2-...

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Bibliografiske detaljer
Main Authors: Gan, Li, Vargas, Marcelo R., Johnson, Delinda A., Johnson, Jeffrey A.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539799/
https://ncbi.nlm.nih.gov/pubmed/23223297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3049-12.2012
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