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Applications of minimal physiologically-based pharmacokinetic models

Conventional mammillary models are frequently used for pharmacokinetic (PK) analysis when only blood or plasma data are available. Such models depend on the quality of the drug disposition data and have vague biological features. An alternative minimal-physiologically-based PK (minimal-PBPK) modelin...

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Detalhes bibliográficos
Main Authors: Cao, Yanguang, Jusko, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539784/
https://ncbi.nlm.nih.gov/pubmed/23179857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-012-9280-2
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