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Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine) has a profound impact on chromatin structure, gene expression and maintenance of cellular identity(1). The recent demonstration that members of the Ten-eleven translocation (Tet) family of proteins can convert 5-me...

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Autors principals: Wu, Hao, D’Alessio, Ana C., Ito, Shinsuke, Xia, Kai, Wang, Zhibin, Cui, Kairong, Zhao, Keji, Sun, Yi Eve, Zhang, Yi
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539771/
https://ncbi.nlm.nih.gov/pubmed/21451524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09934
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