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Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome-w...

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Detalhes bibliográficos
Main Authors: Wu, Hao, D'Alessio, Ana C., Ito, Shinsuke, Wang, Zhibin, Cui, Kairong, Zhao, Keji, Sun, Yi Eve, Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070931/
https://ncbi.nlm.nih.gov/pubmed/21460036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2036011
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