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Cross-Linking of Cell Surface Amyloid Precursor Protein Leads to Increased β-Amyloid Peptide Production in Hippocampal Neurons: Implications for Alzheimer's Disease

The accumulation of the β-amyloid peptide (Aβ) in Alzheimer's disease (AD) is thought to play a causative role in triggering synaptic dysfunction in neurons, leading to their eventual demise through apoptosis. Aβ is produced and secreted upon sequential cleavage of the amyloid precursor protein...

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Autori principali: Lefort, Roger, Pozueta, Julio, Shelanski, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539764/
https://ncbi.nlm.nih.gov/pubmed/22855816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6473-11.2012
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