Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

DNA methylation at proximal promoters facilitates lineage restriction by silencing cell type–specific genes. However, euchromatic DNA methylation frequently occurs in regions outside promoters. The functions of such nonproximal promoter DNA methylation are unclear. Here we show that the de novo DNA...

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Hlavní autoři: Wu, Hao, Coskun, Volkan, Tao, Jifang, Xie, Wei, Ge, Weihong, Yoshikawa, Kazuaki, Li, En, Zhang, Yi, Sun, Yi Eve
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539760/
https://ncbi.nlm.nih.gov/pubmed/20651149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190485
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