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Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
The expression of acid ceramidase (AC) – a cysteine amidase that hydrolyses the proapoptotic lipid ceramide – is abnormally high in several human tumors, which is suggestive of a role in chemoresistance. Available AC inhibitors lack, however, the potency and drug-likeness necessary to test this idea...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3539145/ https://ncbi.nlm.nih.gov/pubmed/23301156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01035 |
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