Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Acid ceramidase (AC) is a lysosomal cysteine amidase that controls sphingolipid signaling by lowering the levels of ceramides and concomitantly increasing those of sphingosine and its bioactive metabolite, sphingosine 1-phosphate. In the present study, we evaluated the role of AC-regulated sphingoli...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Realini, Natalia, Palese, Francesca, Pizzirani, Daniela, Pontis, Silvia, Basit, Abdul, Bach, Anders, Ganesan, Anand, Piomelli, Daniele
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732224/
https://ncbi.nlm.nih.gov/pubmed/26553872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666909
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