Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

Several RNA-targeted therapeutics, including antisense oligonucleotides (ONs), small interfering RNAs, and miRNAs, constitute immunostimulatory CpG motifs as an integral part of their design. The limited success with free antisense ONs in hematologic malignancies in recent clinical trials has been a...

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Bibliografiske detaljer
Main Authors: Yu, Bo, Mao, Yicheng, Bai, Li-Yuan, Herman, Sarah E. M., Wang, Xinmei, Ramanunni, Asha, Jin, Yan, Mo, Xiaokui, Cheney, Carolyn, Chan, Kenneth K., Jarjoura, David, Marcucci, Guido, Lee, Robert J., Byrd, John C., Lee, L. James, Muthusamy, Natarajan
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538326/
https://ncbi.nlm.nih.gov/pubmed/23165478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-407742
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