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How a holoenzyme for DNA replication is formed

Loading of the phage T4 sliding clamp gp45 by the gp44/62 clamp loader onto DNA to form the holoenzyme and their disassembly pathways were investigated using FRET-based single-molecule and ensemble kinetic studies. gp44/62-mediated assembly of gp45 onto the DNA involves a rate-limiting conformationa...

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Sonraí Bibleagrafaíochta
Main Authors: Perumal, Senthil K., Ren, Wenhui, Lee, Tae-Hee, Benkovic, Stephen J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538194/
https://ncbi.nlm.nih.gov/pubmed/23248268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212748110
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