HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism

MHCII proteins bind peptide antigens in endosomal compartments of antigen-presenting cells. The non-classical MHCII protein HLA-DM chaperones peptide-free MHCII against inactivation and catalyzes peptide exchange on loaded MHCII. Another non-classical MHCII protein, HLA-DO, binds HLA-DM and influenc...

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Main Authors: Guce, Abigail I, Mortimer, Sarah E, Yoon, Taejin, Painter, Corrie A, Jiang, Wei, Mellins, Elizabeth D, Stern, Lawrence J
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537886/
https://ncbi.nlm.nih.gov/pubmed/23222639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2460
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