Neutralizing Antibodies and CD8(+) T Lymphocytes both Contribute to Immunity to Adenovirus Serotype 5 Vaccine Vectors

The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 vector-based vaccines for human immunodeficiency virus type 1 and other pathogens. Ad5-specific neutralizing antibodies (NAbs)...

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Bibliographische Detailangaben
Hauptverfasser: Sumida, Shawn M., Truitt, Diana M., Kishko, Michael G., Arthur, Janelle C., Jackson, Shawn S., Gorgone, Darci A., Lifton, Michelle A., Koudstaal, Wouter, Pau, Maria G., Kostense, Stefan, Havenga, Menzo J. E., Goudsmit, Jaap, Letvin, Norman L., Barouch, Dan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC353774/
https://ncbi.nlm.nih.gov/pubmed/14990686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.2666-2673.2004
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