Immunogenicity of Recombinant Fiber-Chimeric Adenovirus Serotype 35 Vector-Based Vaccines in Mice and Rhesus Monkeys

Preexisting immunity to adenovirus serotype 5 (Ad5) has been shown to suppress the immunogenicity of recombinant Ad5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 (HIV-1) in both preclinical studies and clinical trials. A potential solution to this problem is to utilize rAd ve...

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Autors principals: Nanda, Anjali, Lynch, Diana M., Goudsmit, Jaap, Lemckert, Angelique A. C., Ewald, Bonnie A., Sumida, Shawn M., Truitt, Diana M., Abbink, Peter, Kishko, Michael G., Gorgone, Darci A., Lifton, Michelle A., Shen, Ling, Carville, Angela, Mansfield, Keith G., Havenga, Menzo J. E., Barouch, Dan H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280229/
https://ncbi.nlm.nih.gov/pubmed/16254351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.22.14161-14168.2005
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