Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines

DCs are critical for priming adaptive immune responses to foreign antigens. However, the utility of harnessing these cells in vivo to optimize the immunogenicity of vaccines has not been fully explored. Here we investigate a novel vaccine approach that involves delivering synergistic signals that bo...

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Bibliographische Detailangaben
Hauptverfasser: Sumida, Shawn M., McKay, Paul F., Truitt, Diana M., Kishko, Michael G., Arthur, Janelle C., Seaman, Michael S., Jackson, Shawn S., Gorgone, Darci A., Lifton, Michelle A., Letvin, Norman L., Barouch, Dan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC524232/
https://ncbi.nlm.nih.gov/pubmed/15520866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422608
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